Named for California’s northernmost mission of the 21 founded by Franciscan monks from Spain — which lies 2.5 miles south — this grande dame of Wine Country hotels was built in 1927 on the site of an earlier hot springs resort. In more recent years, it’s been renowned for its 40,000-square-foot, European-style Willow Stream Spa, including 30 treatment rooms, mineral water baths, Watsu pool and a custom “rain tunnel.” Excellent dining and drinking options abound, from casually elegant (Sante Kitchen) to just casual (Cali Forno food truck).

Photo: Courtesy of Fairmont Sonoma Mission Inn & Spa