This is 21st century luxury with bells and whistles, but without the grandeur of Nob Hill. An enviable location places guests in the heart of SoMa adjacent to SFMOMA, so it’s a quick walk to museums, Union Square shopping, Yerba Buena Gardens, and the Moscone Convention Center. Rooms have feather-top beds, spacious bathrooms and complimentary Wi-Fi. The 5,700-square-foot fitness center and Remede Spa with heated infinity pool are available to guests.

Photo: Courtesy of St. Regis San Francisco