No city in the world is quite like San Francisco. Once a Spanish mission, San Francisco was defined by “The Gold Rush” — which created a population boom from 1,000 to 25,000 by December 1849 — and by the 1906 Earthquake and Fire, which left 200,000 homeless. It’s now home to nearly 875,000 people, and attracts over 25 million visitors annually. We have gathered all the best hotels to help make your time here as good as it can be.